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PF-06446846 hydrochloride

CAS No. 1632250-50-0

PF-06446846 hydrochloride( —— )

Catalog No. M33462 CAS No. 1632250-50-0

PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 138 Get Quote
5MG 215 Get Quote
10MG 345 Get Quote
25MG 546 Get Quote
50MG 780 Get Quote
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Biological Information

  • Product Name
    PF-06446846 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression.
  • Description
    PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochlorideinhibits PCSK9 by inducing the ribosome to stall around codon 34.
  • In Vitro
    PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM.
  • In Vivo
    PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.Animal Model:Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)Dosage:5, 15, and 50 mg/kg Administration:Oral gavage; daily for 14 daysResult:Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1632250-50-0
  • Formula Weight
  • Molecular Formula
    C22H20CIN7O.XHCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (531.52 mM; Ultrasonic ) H2O : 100 mg/mL (212.61 mM; Ultrasonic)
  • SMILES
    Cl.Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15(3):e2001882.?
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